Synergetic effects of Aerobic Exercise Paired with Non-Invasive Brain Stimulation to Prime Neuroplasticity in Multiple Sclerosis

Studies

Study Title: Synergetic effects of Aerobic Exercise Paired with Non-Invasive Brain Stimulation to Prime Neuroplasticity in Multiple Sclerosis
Rationale: The purpose of this project is to investigate the synergetic effects of physical exercise paired with transcranial direct current stimulation (tDCS) on priming neuroplasticity in people with multiple sclerosis (MS), who, due to extensive brain lesion, have accumulated higher levels of disability.
Study Description: Researchers at the University of Ottawa are seeking volunteers to participate in a study examining the effects of an acute session of aerobic exercise paired with a non-invasive brain stimulation tool called transcranial direct current stimulation (tDCS). This study will examine whether tDCS when performed together with exercise can boost exercise performance and also prime neuroplasticity.
If you are interested and choose to participate, you would be asked to complete four testing visits. The first visit will be at the University of Ottawa (200 Lees Ave, Ottawa, ON), and the following three visits will be at the University of Quebec (283 Boul Alexandre-Taché, Gatineau, QC). Participant will be enrolled to the study on a first-come, first-served basis.
Starting Date: 2022-05-23
Ending Date: 2022-12-31
Who can participate: People living with MS who are 18 years of age or older, relapse-free in the past 30-days, and experience some physical disability (e.g., difficulty with walking, muscle weakness, or coordination challenges) may be eligible to participate. People without MS who are 18 years of age or older may be eligible to participate.
Trial Institution: University of Ottawa
Trial Investigator: Dr. Arthur Chaves
Contact Information: Schuyler Earl
cepl@uottawa.ca
Trial Funding: Natural Sciences and Engineering Research Council of Canada Discovery Grant (RGPIN-2020-05856); Canadian Foundation for Innovation; Ministry of Research and Innovation (149916; 149917); Ontario Ministry of Economic Development, Job Creation and Trade (151030); Post-Doctoral Fellowship: uOttawa / CHEO Research Institute Collaborative Initiative and Physical Activity and Health